ASYMMETRIC REDUCTION OF KARAHANAEUONE WITH VARIOUS MICROORGANISMS

Both enantiomers of karahanaenol have been prepared by microbial asymm etric reduction of karahanaenone. The (S)-enantiomer with high enantio meric excess was obtained by Glomerella cingulata, Aspergillus niger, Streptomyces aureofaciens and Bacillus subtilis respectively. In contr ast,the (R)-enantiomer of karahanaenol was obtained with Fusarium sola ni.