It is shown that, due to topological obstructions, the effective actio
n of a gauge theory in a multiple-connected space-time containing one
fermion n-plet in the fundamental representation of the covering group
of the gauge group is not, in general, BRST-invariant. A resolution t
o this problem is attained with the introduction of identical copies o
f the original n-plet, one for each of the effectively independent com
ponents of the symmetry group, and a truly invariant generating functi
onal is constructed. Examples with explicit gauge groups and their pos
sible relevance to the family problem or to the SU(3) flavors of quark
s are briefly discussed.