SILICON-DIRECTED ASYMMETRIC-SYNTHESIS OF (IR, 2S)-(-)-(1,2-EPOXYPROPYL)PHOSPHONIC ACID (FOSFOMYCIN) FROM (S)-LACTALDEHYDE

Authors
BANDINI E MARTELLI G SPUNTA G PANUNZIO M
Citation
E. Bandini et al., SILICON-DIRECTED ASYMMETRIC-SYNTHESIS OF (IR, 2S)-(-)-(1,2-EPOXYPROPYL)PHOSPHONIC ACID (FOSFOMYCIN) FROM (S)-LACTALDEHYDE, Tetrahedron : asymmetry, 6(9), 1995, pp. 2127-2130
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
9
Year of publication
1995
Pages
2127 - 2130
Database
ISI
SICI code
0957-4166(1995)6:9<2127:SAO(2>2.0.ZU;2-4
Abstract
The title compound is obtained in high diastereomeric purity based on the stereoselective addition of trimethylsilyldibenzylphosphite (TMSDB P) to O-triisopropylsilyloxy (S)-lactaldehyde.