AMELIORATIVE ROLE OF AMINO-ACIDS ON FLUORIDE-INDUCED ALTERATIONS IN MICE (PART II) - OVARIAN AND UTERINE NUCLEIC-ACID METABOLISM

Sodium fluoride (5 mg/kg body weight) was effective from the 45th day of treatment in causing a significant decline in DNA and RNA levels of mice ovary and uterus, indicating alterations in nucleic acid and pro tein metabolism in these organs. The oestrus cycle was irregular with prolonged duration of the diestrus stage which in turn severely affect ed the fertility rate in treated mice. The administration of amino aci ds glycine and glutamine, individually and in combination along with N aF, helped in maintaining the status quo of all parameters as compared to control, thus elucidating their ameliorative role.