A MODEL STUDY ON THE MECHANISM OF INHIBITION OF FATTY ACYL DESATURASES BY CYCLOPROPENE FATTY-ACIDS

Authors
QUINTANA J BARROT M FABRIAS G CAMPS F
Citation
J. Quintana et al., A MODEL STUDY ON THE MECHANISM OF INHIBITION OF FATTY ACYL DESATURASES BY CYCLOPROPENE FATTY-ACIDS, Tetrahedron, 54(34), 1998, pp. 10187-10198
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
34
Year of publication
1998
Pages
10187 - 10198
Database
ISI
SICI code
0040-4020(1998)54:34<10187:AMSOTM>2.0.ZU;2-#
Abstract
1,2-dialkylcyclopropenes, but not the corresponding 3-carboxycycloprop ene or cyclopropenone derivatives, react with 1-propanethiol to give a lkylthiocyclopropanes. None of the cyclopropenes and cyclopropene deri vatives investigated reacted with other aminoacid chemical probes. The se overall results support that inhibition of desaturases by cycloprop ene fatty acids is caused by reaction of the unsaturated moiety with a cysteine residue of the enzyme active site. (C) 1998 Elsevier Science Ltd. All rights reserved.