ISOLATION AND STRUCTURE ELUCIDATION OF TSUGICOLINES F-H, NOVEL FUROSESQUITERPENES, AND TSUGICOLINE-I FROM THE FUNGUS LAURILIA-TSUGICOLA

Three novel sesquiterpenes of protoilludane origin, tsugicolines F-H ( 4a-6a), have been isolated from solid cultures of the Basidiomycetae L aurilia tsugicola. Their structures were elucidated by means of chemic al correlation and NMR studies; a possible pathway for the formation f rom the protoilludane derivative tsugicoline A is reported. The furose squiterpenes 4a and 5a are weakly active on bacteria but inhibited the germination of the water cress Lepidium sativum. A fourth metabolite, the norsesquiterpene tsugicoline I 7, was also isolated from the same fungus. (C) 1998 Elsevier Science Ltd. All rights reserved.