We have developed a new method for HPLC which uses packing materials m
odified with a temperature-responsive polymer, poly(N-isopropylacrylam
ide). The surface properties and functions of the stationary phases ar
e controlled by the external temperature. In the proposed chromatograp
hic system, the elution of target substances is controlled by only a s
mall change in the column temperatures. (C) 1998 Elsevier Science B.V.
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