BONE-MARROW DONORS WORLDWIDE AND CORD-BLOOD STEM-CELL TRANSPLANTATION

Stem cell transplantation using cord blood donors mismatched for one o r two HLA antigens can be successful. A simulation study was performed to assess the percentage of patients for whom a matched and/or a one or two antigen mismatched donor is available, Using either bone marrow donors worldwide (BMDW) (n = 925 109) or the cord blood donor file in BMDW (n = 11 049). As a donor source, for 97% of the Dutch patients a 0 or 1 antigen mismatched cord blood donor was available, for patient s from the minority groups this percentage was 55%, These percentages compare favourably with the fraction of 0 mismatched donors found in B MDW.