UNRELATED MISMATCHED CORD-BLOOD TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES - A SINGLE INSTITUTION EXPERIENCE

We report on six cases of unrelated UCB transplant in adult patients w ith hematological malignancies: three chronic myelocytic leukemias and three acute leukemias, Their median age and body weight were respecti vely: 28 years (range 15.5-40) and 55.5 kg (range 46-90). The cord blo od units were from the New York Blood Center, The median number of nuc lear cells provided, evaluated before thawing, was 2.1 x 10(7)/kg (ran ge 1 x 10(7)/kg-4.7 x 10(7)/kg). The degree of HLA disparity was 1/6: two patients, 2/6: three patients, 3/6: one patient. The patients rece ived a pretransplant regimen including total body irradiation. They we re given graft-versus-host disease prophylaxis which consisted of cycl osporin A and corticosteroids. They were all given a combination of G- CSF and erythropoietin. The median time of white blood cell and platel et reconstitution were respectively 24 days (range 12-43) and 60 days (range 23-90), All the patients had a full chimerism, A grade I acute GVHD was observed in four patients and two patients do not have any GV HD. No chronic GVHD has been observed yet. Three patients died from to xicity. Three patients are alive and well in complete remission at 2 y ears, 1 year and 11 months post-graft.