Previous conclusions regarding the role of social support in hemodialy
sis adherence are inconsistent, suggesting that other factors may mode
rate this relationship. Using the Five-Factor Model of Personality, we
examined the hypothesis that conscientiousness would interact with so
cial support in predicting fluid-intake and medication adherence in a
sample of 56 chronic hemodialysis patients. Hierarchical regression an
alyses (controlling for demographic, clinical, and other personality v
ariables) revealed a significant interaction between social support an
d conscientiousness. However inconsistent with prediction, high suppor
t among patients with low conscientiousness was associated with poorer
fluid-intake adherence, while support had little effect on fluid-inta
ke adherence among high conscientiousness patients. No main or interac
tive effects were found for support or conscientiousness on a measure
of medication adherence.