PSA-DENSITY AS A PROGNOSTIC FACTOR FOR LO CALIZED PROSTATE-CANCER

The sensitivity and specificity of prostate-specific antigen density ( PSAD), a quotient of serum PSA and prostate volume, in the detection o f localized prostate cancer was analysed in a prospective study. A tot al of 235 patients were examined, 145 without prostate cancer and 90 p atients before radical prostatectomy for localized prostate cancer. PS AD was determined by dividing the serum level of PSA by the volume of the entire prostate (estimated by transrectal ultrasound) and multiply ing by 100. Using a PSAD of 15, the specificity achieved in our collec tive was the same as with an absolute PSA value of 4 ng/ml (88.9-90%). On the other hand, with the PSAD of 15 we also found the same sensiti vity as with an ab-solute PSA of 10 ng/ml (75.2-76.5%).