G. Richterlevin et al., DISSOCIATION BETWEEN GENES ACTIVATED IN LONG-TERM POTENTIATION AND INSPATIAL-LEARNING IN THE RAT, Neuroscience letters, 251(1), 1998, pp. 41-44
We have compared changes in mRNA of three genes, zif268, raf B, and sy
ntaxin 1B, following the unilateral induction of longterm potentiation
(LTP) in rats previously trained in a water maze, and in behaviourall
y naive animals. mRNA of all three genes was enhanced in the potentiat
ed dentate gyrus of naive animals 3 h after the induction of LTP. Trai
ning did not affect expression of mRNA for zif268 or for syntaxin IB.
Expression of raf B was enhanced by training, and in trained animals t
he LTP-associated increase in expression of raf B was occluded. These
results suggest that LTP and spatial training engage a common pathway
utilizing an increase in mRNA for raf B, and demonstrate a dissociatio
n between LTP and spatial learning with respect to expression of zif26
8 and syntaxin 1B. (C) 1998 Elsevier Science Ireland Ltd. All rights r
eserved.