MYELOID AND LYMPHOID RECOVERY FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION - A COMPARATIVE-STUDY BETWEEN RELATED, UNRELATED BONE-MARROWAND ALLOGENEIC PERIPHERAL STEM-CELL TRANSPLANTATION

We studied myeloid and lymphoid recovery during a period of 12 months following HLA matched allogeneic bone marrow transplantation (BMT) in 15 patients. Patients were divided into three groups. Each group conta ined 5 patients according to the source of hematopoietic stem cell tra nsplantation (HST): 1) related bone marrow transplantation (BMT), 2) a llogeneic peripheral blood stem cell transplantation (PBSCT) and 3) ma tched unrelated donor transplantation (MUD). The rate and pattern of r ecovery of granulocytes, lymphocytes (T-cell subsets, B-cells, Mt cell s, subsets of CD45) were studied by cell counting and flow cytometry. Our results suggest faster recovery of PMN after PBSCT. Higher CD4 cel l counts observed in the PBSCT group may have an impact on a lower inc idence of opportunistic infections. Chronic GVHD mediated GvL effect s eems to be more important in blood stem cell transplanted patients and this may have an influence on disease free survival.