D. Horak et al., RADIOPAQUE POLY(2-HYDROXYETHYL METHACRYLATE) PARTICLES CONTAINING SILVER-IODIDE COMPLEXES TESTED ON CELL-CULTURE, Biomaterials, 19(14), 1998, pp. 1303-1307
Silver iodide complexes have been used as an effective radiopacifying
agent to prepare radiopaque poly(2-hydroxyethyl methacrylate) (poly(HE
MA)) particles. Incorporation of silver iodide complexes inside the po
ly(HEMA) particles was achieved by first swelling particles in potassi
um iodide solution and precipitating the silver iodide complexes using
a 30 wt% solution of silver nitrate. The dry particles contained 15 w
t% of silver iodide complexes. Particles were easily monitored using a
standard imaging technique based on X-ray absorption. Toxicity of the
particles has been determined in in vitro experiments on a cell cultu
re. As no inhibition of growth of cells surrounding the particles was
observed, they can be considered non-toxic. (C) 1998 Elsevier Science
Ltd. All rights reserved.