AGE-DEPENDENT AND TEMPERATURE-DEPENDENT EFFECTS OF OPIOIDS ON MEDULLA-OBLONGATA RESPIRATORY ACTIVITY - AN IN-VITRO STUDY IN NEWBORN RAT

Authors
TAKITA K HERLENIUS E LINDAHL SGE YAMAMOTO Y
Citation
K. Takita et al., AGE-DEPENDENT AND TEMPERATURE-DEPENDENT EFFECTS OF OPIOIDS ON MEDULLA-OBLONGATA RESPIRATORY ACTIVITY - AN IN-VITRO STUDY IN NEWBORN RAT, Brain research, 800(2), 1998, pp. 308-311
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
800
Issue
2
Year of publication
1998
Pages
308 - 311
Database
ISI
SICI code
0006-8993(1998)800:2<308:AATEOO>2.0.ZU;2-T
Abstract
Influences of post-natal age (P0-P4) and temperature (22.5 degrees-31. 5 degrees C) on the action(s) of opioids on respiratory activities fro m neonatal rat brainstem-spinal cord preparations were examined in thi s study. A temperature-dependent mu-opioid receptor effect on respirat ion was found. In addition, the effect of morphine increased with post natal age (P0-P4). Hence, age and temperature must be taken into accou nt when performing studies on medullary respiration-related structures using the neonatal rat brainstem-spinal cord preparation. (C) 1998 Pu blished by Elsevier Science B.V. All rights reserved.