KAINIC ACID-INDUCED PERIRHINAL CORTICAL SEIZURES IN RATS

Seizures induced in rats by kainic acid microinjection into the perirh inal cortex were studied electrophysiologically and behaviorally and c ompared with known features of seizures following kainic acid injectio n into the amygdala. Unlike amygdalar seizures, perirhinal cortical se izures did not generalize to become Limbic seizures but rather spread to sensorimotor cortex to become manifest as motor seizures. Perirhina l cortical seizures also required larger kainic acid doses for provoca tion and were briefer. (C) 1998 Elsevier Science B.V. All rights reser ved.