Four children are presented and their eye malformations described. One
girl had bilateral anophthalmos, a boy and a girl had bilateral sever
e microphthalmos, and a boy had a unilateral optic disc coloboma. The
mothers of all four children were treated with carbamazepine during pr
egnancy. The teratogenic effect of carbamazepine and its likely role i
n the genesis of the eye malformations is discussed.