DEREGULATED EXPRESSION OF THE TAL1 GENE BY T(1-5)(P32-Q31) IN PATIENTWITH T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA

TALI gene deregulation is frequent in T-cell acute lymphoblastic leuke mia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome I. This study presents a case of T-ALL with a t(1;5)(p3 2;q31) involving TAL I, in which the breakpoint occurs approximately 1 0 kbp 5' to the gene and leads to transcriptional activation and synth esis of a TALI protein, and extends the spectrum of recognized TALI ge ne translocations associated with T-ALL. (C) 1998 Wiley-Liss, Inc.