STEREOSELECTIVE SYNTHESES OF (-TERCONAZOLE AND (-)-TERCONAZOLE())

Authors
CAMPS P FARRES X GARCIA ML MAULEON D CARGANICO G
Citation
P. Camps et al., STEREOSELECTIVE SYNTHESES OF (-TERCONAZOLE AND (-)-TERCONAZOLE()), Tetrahedron : asymmetry, 6(9), 1995, pp. 2365-2368
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
6
Issue
9
Year of publication
1995
Pages
2365 - 2368
Database
ISI
SICI code
0957-4166(1995)6:9<2365:SSO(A(>2.0.ZU;2-Z
Abstract
The recently described cis-benzoates (2R,4R)- and (2S,4S)-2 were trans formed into (+)- and (-)-terconazole, respectively, by reaction with 1 H-1,2,4-triazole followed by hydrolysis to give alcohols (+)- and (-)- 3 which were mesylated and reacted with phenol 5. The ee's of (+)-and( -)-terconazole determined by HPLC on the CSP Chiralcel OD-H were > 99% .