A ROLE FOR TH1 AND TH2 CELLS IN THE IMMUNOPATHOGENESIS OF ATOPIC-DERMATITIS

Authors
GREWE M BRUIJNZEELKOOMEN CAFM SCHOPF E THEPEN T LANGEVELDWILDSCHUT AG RUZICKA T KRUTMANN J
Citation
M. Grewe et al., A ROLE FOR TH1 AND TH2 CELLS IN THE IMMUNOPATHOGENESIS OF ATOPIC-DERMATITIS, Immunology today, 19(8), 1998, pp. 359-361
Citations number
41
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
19
Issue
8
Year of publication
1998
Pages
359 - 361
Database
ISI
SICI code
0167-5699(1998)19:8<359:ARFTAT>2.0.ZU;2-O
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characte rized by intensely pruritic subacute and chronic eczematous plaques, t he pathogenesis of which appears to involve a complex interplay of gen etic, pharmacological, environmental and psychological factors. Here, Markus Grewe and colleagues propose that the development of skin lesio ns in AD patients results from sequential activation of T helper 2 (Th 2)- and Th1-type cells.