NEVER SYNTHESIS OF A WATER-SOLUBLE CYCLODEXTRIN-POLYMER HAVING A CHITOSAN SKELETON

Formation of Schiff's base between 2-O-(formylmethyl)-beta-cyclodextri n and chitosan with an average molecular weight of 40 000 in acetate b uffer at pH 4.4, followed by reduction with sodium cyanoborohydride pr oduced a beta-cyclodextrin-linked chitosan in a one-pot reaction. The product, which had a degree of substitution of 37%, was soluble in wat er at neutral and alkaline conditions. UV-visible and circular dichroi sm spectroscopic examinations revealed that the product had the abilit y to form a host-guest complex with p-nitrophenolate. (C) 1998 Elsevie r Science Ltd. All rights reserved.