RHABDOMYOLYSIS ASSOCIATED WITH CLOZAPINE TREATMENT IN A PATIENT WITH DECREASED CALCIUM-DEPENDENT POTASSIUM PERMEABILITY OF CELL-MEMBRANES

Authors
KOREN W KOREN E NACASCH N EHRENFELD M GUR H
Citation
W. Koren et al., RHABDOMYOLYSIS ASSOCIATED WITH CLOZAPINE TREATMENT IN A PATIENT WITH DECREASED CALCIUM-DEPENDENT POTASSIUM PERMEABILITY OF CELL-MEMBRANES, Clinical neuropharmacology, 21(4), 1998, pp. 262-264
Citations number
19
Categorie Soggetti
Clinical Neurology","Pharmacology & Pharmacy
Journal title
Clinical neuropharmacology → ACNP
ISSN journal
03625664
Volume
21
Issue
4
Year of publication
1998
Pages
262 - 264
Database
ISI
SICI code
0362-5664(1998)21:4<262:RAWCTI>2.0.ZU;2-W
Abstract
A 21-year-old patient developed rhabdomyolysis during his nineteenth w eek of treatment with clozapine for drug-resistant schizophrenia. No r isk factors for rhabdomyolysis were found, but the calcium-dependent p otassium efflux, normally responsible for membrane hyperpolarization a nd muscle refractoriness, was severely decreased in the patient's red blood cells. Clozapine is speculated to cause rhabdomyolysis in patien ts with defective calcium-activated K+ channels.