RESOLUTION OF (4-AMINO-3-CHLORO-5-CYANOPHENYL)-2-BROMO-1-ETHANOL BY LIPASE-MEDIATED ENANTIOSELECTIVE ALCOHOLYSIS, HYDROLYSIS AND ACYLATION

Authors
CONDE S FIERROS M RODRIGUEZFRANCO MI PUIG C
Citation
S. Conde et al., RESOLUTION OF (4-AMINO-3-CHLORO-5-CYANOPHENYL)-2-BROMO-1-ETHANOL BY LIPASE-MEDIATED ENANTIOSELECTIVE ALCOHOLYSIS, HYDROLYSIS AND ACYLATION, Tetrahedron : asymmetry, 9(13), 1998, pp. 2229-2232
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
13
Year of publication
1998
Pages
2229 - 2232
Database
ISI
SICI code
0957-4166(1998)9:13<2229:RO(BL>2.0.ZU;2-Y
Abstract
Resolution of (4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol has b een achieved by ethanol enantio-selective lipase-catalysed alcoholysis , hydrolysis and acylation. Although a good enantioselectivity was obs erved in the three reactions, the best results were obtained by hydrol ysis. This alpha-bromohydrin is an intermediate in the synthesis of a new adrenergic agent. (C) 1998 Elsevier Science Ltd. All rights reserv ed.