NEW OPTICALLY-ACTIVE AMIDO-PHOSPHINITE LIGAND AND RUTHENIUM COMPLEXES

Authors
LEGENDRE P OFFENBECHER M BRUNEAU C DIXNEUF PH
Citation
P. Legendre et al., NEW OPTICALLY-ACTIVE AMIDO-PHOSPHINITE LIGAND AND RUTHENIUM COMPLEXES, Tetrahedron : asymmetry, 9(13), 1998, pp. 2279-2284
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
13
Year of publication
1998
Pages
2279 - 2284
Database
ISI
SICI code
0957-4166(1998)9:13<2279:NOALAR>2.0.ZU;2-A
Abstract
The hydrogenation of acetoacetanilide in the presence of optically act ive ruthenium catalysts leads to 3-hydroxy-N-phenylbutanamide in good yield anti high enantioselectivity (ee>95%). Its direct phosphinylatio n with chlorodiphenylphosphine affords a new bifunctional amido-phosph inite ligand that can easily be coordinated to [(arene)RuCl2] and to t he CpRuCl(PPh3) moiety with very good stereoselectivity from CpRuCl(PP h3)(2). (C) 1998 Elsevier Science Ltd. All rights reserved.