ENANTIOSELECTIVE SYNTHESIS OF 20(S)-CAMPTOTHECIN USING AN ENZYME-CATALYZED RESOLUTION

Authors
IMURA A ITOH M MIYADERA A
Citation
A. Imura et al., ENANTIOSELECTIVE SYNTHESIS OF 20(S)-CAMPTOTHECIN USING AN ENZYME-CATALYZED RESOLUTION, Tetrahedron : asymmetry, 9(13), 1998, pp. 2285-2291
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
13
Year of publication
1998
Pages
2285 - 2291
Database
ISI
SICI code
0957-4166(1998)9:13<2285:ESO2UA>2.0.ZU;2-8
Abstract
The important key intermediate of a 20(S)-camptothecin synthesis was p repared enantioselectively using an enzyme-catalyzed resolution. A com mercially available papain was found to exhibit the highest enantiosel ectivity with moderate activity, and the (S)-enantiomer of 99% ee was obtained as the remaining substrate. (C) 1998 Elsevier Science Ltd. Al l rights reserved.