AGOSTEROL-A, A NOVEL POLYHYDROXYLATED STEROL ACETATE REVERSING MULTIDRUG-RESISTANCE FROM A MARINE SPONGE OF SPONGIA SP

Authors
AOKI S YOSHIOKA Y MIYAMOTO Y HIGUCHI K SETIAWAN A MURAKAMI N CHEN ZS SUMIZAWA T AKIYAMA S KOBAYASHI M
Citation
S. Aoki et al., AGOSTEROL-A, A NOVEL POLYHYDROXYLATED STEROL ACETATE REVERSING MULTIDRUG-RESISTANCE FROM A MARINE SPONGE OF SPONGIA SP, Tetrahedron letters, 39(35), 1998, pp. 6303-6306
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
35
Year of publication
1998
Pages
6303 - 6306
Database
ISI
SICI code
0040-4039(1998)39:35<6303:AANPSA>2.0.ZU;2-8
Abstract
Agosterol A (1) has been isolated from a marine sponge of Spongia sp. and the absolute stereostructure elucidated. Agosterol A (1) is a nove l polyhydroxylated sterol acetate, which completely reverses multidrug resistance in human carcinoma cells caused by overexpression of two k inds of membrane glycoprotein. (C) 1998 Elsevier Science Ltd. All righ ts reserved.