The triple-phase bone scan is frequently used in the diagnosis of refl
ex sympathetic dystrophy although the etiology of the abnormal finding
s is not well established. This study evaluated the effect of increase
d blood flow secondary to sympathetic block on the triple-phase bone s
can. In 15 reflex sympathetic dystrophy patients, all of whom had sign
ificant relief with sympathetic block, baseline and postsympathetic bl
ock bone scans were analyzed. There was a significant linear relations
hip between change in counts from baseline to postsympathetic block on
the blood pool image and bone uptake image. As the blood pool and bon
e uptake counts increased, the likelihood of typical reflex sympatheti
c dystrophy findings on visual inspection also increased. These result
s strongly support the concept of increased vascular flow as the cause
of increased periarticular uptake.