SEQUENCE-ANALYSIS OF HEPATITIS-B VIRUS GENOME ISOLATED FROM SERUM OF SUCCESSFULLY-PROPHYLACTED INFANTS

Authors
SUGIYAMA K GOTO K ANDO T
Citation
K. Sugiyama et al., SEQUENCE-ANALYSIS OF HEPATITIS-B VIRUS GENOME ISOLATED FROM SERUM OF SUCCESSFULLY-PROPHYLACTED INFANTS, Hepatology research, 12(1), 1998, pp. 45-49
Citations number
15
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Hepatology research → ACNP
ISSN journal
13866346
Volume
12
Issue
1
Year of publication
1998
Pages
45 - 49
Database
ISI
SICI code
1386-6346(1998)12:1<45:SOHVGI>2.0.ZU;2-L
Abstract
The sequences of hepatitis B virus (HBV) genomes isolated from the ser um of five infants born to hepatitis B e antigen (HBeAg)-positive-carr ier mothers were analyzed. All infants were protected against perinata l infection of HBV by immune prophylaxis that was judged successful. A lthough HBV variants with mutation(s) or deletion(s), in the preS, cor e promoter and preC genes, which are believed to be directly related t o the negative serum marker for HBV infection, were not found in any o f the infants, hepatitis B surface antibody (anti-HBs) escape mutant H BV was found in two infants. (C) 1998 Elsevier Science Ireland Ltd. Al l rights reserved.