POWDER DENSIFICATION - 2 - VISCOELASTIC MATERIAL PROPERTIES IN MODELING THE UNIAXIAL COMPACTION OF POWDERS

Citation
Sk. Lum et al., POWDER DENSIFICATION - 2 - VISCOELASTIC MATERIAL PROPERTIES IN MODELING THE UNIAXIAL COMPACTION OF POWDERS, Journal of pharmaceutical sciences, 87(8), 1998, pp. 909-916
Citations number
25
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy",Chemistry
ISSN journal
00223549
Volume
87
Issue
8
Year of publication
1998
Pages
909 - 916
Database
ISI
SICI code
0022-3549(1998)87:8<909:PD-2-V>2.0.ZU;2-2
Abstract
A micromechanical model for predicting the densification of particulat e matter under hydrostatic loading was developed to account for the ti me-dependent response of materials to applied loads. Viscoelastic mate rial response used in the analysis was based upon a standard three-par ameter rheological model. Compaction data under closed die conditions were collected using an Instron analyzer for different rates of applie d load. Densification during the loading phase of PMMA/coMMA powder, a pharmaceutical polymeric coating material, was well predicted by the proposed algorithm, which contrasts with the prediction implied throug h a static indentation model. Secondary factors which affect compactio n such as die-wall friction are also briefly discussed.