AUTOSOMAL-DOMINANT INHERITANCE OF ADDUCTED THUMBS AND OTHER DIGITAL ANOMALIES

Isolated adducted thumbs is an uncommon malformation that occurs spora dically in the majority of cases although some affected families have been reported. Previously, autosomal dominant inheritance was suggeste d in two familial cases, but this mode of inheritance has not been con firmed. Here we describe a family with adducted thumbs and other digi tal anomalies in which seven members (six females and one male) are af fected in three consecutive generations. Additionally, the patients sh owed mild abnormalities of fingers 2nd-4th bilaterally and hypoplasia of the middle phalanx of the 5th fingers. This family represents an au tosomal dominant condition that apparently has not been previously rep orted. (C) Munksgaard, 1998.