BUFFERING - A POSSIBLE PASSIVE-HOMEOSTASIS ROLE FOR REDUNDANT DNA

Authors
VINOGRADOV AE
Citation
Ae. Vinogradov, BUFFERING - A POSSIBLE PASSIVE-HOMEOSTASIS ROLE FOR REDUNDANT DNA, Journal of theoretical biology, 193(2), 1998, pp. 197-199
Citations number
30
Categorie Soggetti
Biology,"Biology Miscellaneous
Journal title
Journal of theoretical biology → ACNP
ISSN journal
00225193
Volume
193
Issue
2
Year of publication
1998
Pages
197 - 199
Database
ISI
SICI code
0022-5193(1998)193:2<197:B-APPR>2.0.ZU;2-F
Abstract
A new general role for redundant (apparently non-coding) DNA is specul ated: buffering the effect of fluctuations in intra-cellular solute co mposition on chromatin condensation state in its condensed form and on binding of DNA-tropic proteins and other ligands in its decondensed f orm. The ''buffering'' DNA performing such passive-homeostasis (energy -independent) function, can provide selective advantage in ecological niches with a low energy supply. (C) 1998 Academic Press