Serotonergic drugs have been proven to be helpful to alcoholics in mai
ntaining abstinence. In this open study, we report that the atypical a
ntidepressant trazodone at low doses was able to significantly decreas
e craving for alcohol, depressive, and anxious symptoms in a number (2
5) of detoxified alcohol-dependent subjects after 3 months of treatmen
t. Trazodone may, therefore. be an adjuvant in the therapy of alcoholi
sm.