SCREENING AND IDENTIFICATION OF SUMATRIPTAN AND ITS MAIN METABOLITE BY MEANS OF THIN-LAYER CHROMATOGRAPHY, ULTRAVIOLET SPECTROSCOPY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

Authors
ROCHHOLZ G AHRENS B KONIG F SCHUTZ HW SCHUTZ H SENO H
Citation
G. Rochholz et al., SCREENING AND IDENTIFICATION OF SUMATRIPTAN AND ITS MAIN METABOLITE BY MEANS OF THIN-LAYER CHROMATOGRAPHY, ULTRAVIOLET SPECTROSCOPY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY, Arzneimittel-Forschung, 45-2(9), 1995, pp. 941-946
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
45-2
Issue
9
Year of publication
1995
Pages
941 - 946
Database
ISI
SICI code
0004-4172(1995)45-2:9<941:SAIOSA>2.0.ZU;2-8
Abstract
Sumatriptan (CAS 103628-46-2, )ethyl]-N-methyl-1H-indole-5-methanesulp honamide), a substance for treatment of acute migraine attacks, and it s main metabolite are investigated by thin-layer chromatography (TLC), ultraviolet spectroscopy, and gas chromatography/mass spectrometry (G C/MS). The resulting analytical data (corrected hR(f)-values, UV solve nt spectra, remission spectra, GC retention indices, and electron impa ct (EI) mass spectra) including an extraction procedure and differ ent derivatization methods are presented. Their applicability is describe d for urine analysis.