SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - II - 8-(FLUORO-SUBSTITUTED PYRROLIDINYL)-2-PYRIDONES AS ANTIBACTERIAL AGENTS

Authors
LI Q WANG WB BERST KB CLAIBORNE A HASVOLD L RAYE K TUFANO M NILIUS A SHEN LL FLAMM R ALDER J MARSH K CROWELL D CHU DTW PLATTNER JJ
Citation
Q. Li et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-PYRIDONES - II - 8-(FLUORO-SUBSTITUTED PYRROLIDINYL)-2-PYRIDONES AS ANTIBACTERIAL AGENTS, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 1953-1958
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
1953 - 1958
Database
ISI
SICI code
0960-894X(1998)8:15<1953:SASO2->2.0.ZU;2-C
Abstract
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, ma king them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has bee n synthesized and their antibacterial activities and pharmacokinetic p roperties are reported. (C) 1998 Elsevier Science Ltd. All rights rese rved.