PEPTIDYL CHEMOSENSORS INCORPORATING A FRET MECHANISM FOR DETECTION OFNI(II)

Authors
PEARCE DA WALKUP GK IMPERIALI B
Citation
Da. Pearce et al., PEPTIDYL CHEMOSENSORS INCORPORATING A FRET MECHANISM FOR DETECTION OFNI(II), Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 1963-1968
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
1963 - 1968
Database
ISI
SICI code
0960-894X(1998)8:15<1963:PCIAFM>2.0.ZU;2-D
Abstract
Hexapeptides incorporating two fluorophores flanking a tripeptide sequ ence that binds Ni(II) and Cu(II) with high affinity have been synthes ized. While Cu(II) quenches the fluorescence of the resulting peptides , coordination of Ni(II) enables enhanced FRET (fluorescent resonance energy transfer) from one fluorophore to the other. (C) 1998 Elsevier Science Ltd. All rights reserved.