ACTINOMYCIN-D, ACTINOMYCIN-C-2 AND ACTINOMYCIN-VII, INHIBITORS OF GRB2-SHC INTERACTION PRODUCED BY STREPTOMYCES

Authors
NAM JY KIM HK SON KH KIM SU KWON BM HAN MY CHUNG YJ BOK SH
Citation
Jy. Nam et al., ACTINOMYCIN-D, ACTINOMYCIN-C-2 AND ACTINOMYCIN-VII, INHIBITORS OF GRB2-SHC INTERACTION PRODUCED BY STREPTOMYCES, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 2001-2002
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
2001 - 2002
Database
ISI
SICI code
0960-894X(1998)8:15<2001:AAAAIO>2.0.ZU;2-M
Abstract
Actinomycin D, C-2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 mu M) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first ex amples of nonphosphorylated natural ligands of SH2 domain. (C) 1998 El sevier Science Ltd. All rights reserved.