DIASTEREOSELECTIVE 2-DIRECTIONAL SYNTHESIS AND CATION-TRANSPORT ABILITY OF THE CENTRAL TRISTETRAHYDROFURANYL UNIT OF MESO POLYETHER GLABRESCOL AS NATURALLY-OCCURRING PODAND

Authors
MORIMOTO Y IWAI T YOSHIMURA T KINOSHITA T
Citation
Y. Morimoto et al., DIASTEREOSELECTIVE 2-DIRECTIONAL SYNTHESIS AND CATION-TRANSPORT ABILITY OF THE CENTRAL TRISTETRAHYDROFURANYL UNIT OF MESO POLYETHER GLABRESCOL AS NATURALLY-OCCURRING PODAND, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 2005-2010
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
2005 - 2010
Database
ISI
SICI code
0960-894X(1998)8:15<2005:D2SACA>2.0.ZU;2-W
Abstract
The diastereoselective synthesis of the central 2,5-linked tristetrahy drofuran (trisTHF) 6 of naturally occurring meso polyether, glabrescol (5), has been achieved in a two-directional manner by the vanadium(v) -catalyzed anti oxidative cyclizations of diol 14. The trisTHF podand 6 and its stereoisomeric analogs 7 and 8 exhibited outstanding cation transport abilities for physiologically important Na+ and K+. (C) 1998 Elsevier Science Ltd. All rights reserved.