SYNTHESIS AND ANTIBACTERIAL IN-VITRO ACTIVITY OF NOVEL ANALOGS OF NEMATOPHIN

Authors
HIMMLER T PIRRO F SCHMEER N
Citation
T. Himmler et al., SYNTHESIS AND ANTIBACTERIAL IN-VITRO ACTIVITY OF NOVEL ANALOGS OF NEMATOPHIN, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 2045-2050
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
2045 - 2050
Database
ISI
SICI code
0960-894X(1998)8:15<2045:SAAIAO>2.0.ZU;2-9
Abstract
The synthesis and in vitro antibacterial activity of new derivatives a nd analogues of nematophin are described. It was shown that the unsubs tituted amide NH-group is essential for bioactivity. Alkyl- or aryl-su bstitution at the 1-position results in a distinct increase of antibac terial activity. Addition of protein (blood or serum) to the culture m edia reduces the inhibitory activity on bacteria. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.