A SYNTHETIC ACCEPTOR SUBSTRATE FOR TRYPANOSOMA-BRUCEI UDP-GAL - GPI ANCHOR SIDE-CHAIN ALPHA-GALACTOSYLTRANSFERASES

Authors
BROWN JR SMITH TK FERGUSON MAJ FIELD RA
Citation
Jr. Brown et al., A SYNTHETIC ACCEPTOR SUBSTRATE FOR TRYPANOSOMA-BRUCEI UDP-GAL - GPI ANCHOR SIDE-CHAIN ALPHA-GALACTOSYLTRANSFERASES, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 2051-2054
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
2051 - 2054
Database
ISI
SICI code
0960-894X(1998)8:15<2051:ASASFT>2.0.ZU;2-Z
Abstract
A synthetic analogue of a trisaccharide fragment of the Trypanosoma br ucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serv es as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alph a-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.