Lipopeptides are potent adjuvants that trigger an immune response agai
nst covalently conjugated low molecular mass antigens. We report here
the design and synthesis of thiol-reactive lipopeptides (6, 7) which c
an be incorporated into liposomes and react, under mild conditions, wi
th synthetic peptides carrying a thiol function. (C) 1998 Elsevier Sci
ence Ltd. All rights reserved.