DESIGN AND SYNTHESIS OF THIOL-REACTIVE LIPOPEPTIDES

Authors
BOECKLER C FRISCH B SCHUBER F
Citation
C. Boeckler et al., DESIGN AND SYNTHESIS OF THIOL-REACTIVE LIPOPEPTIDES, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 2055-2058
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
15
Year of publication
1998
Pages
2055 - 2058
Database
ISI
SICI code
0960-894X(1998)8:15<2055:DASOTL>2.0.ZU;2-C
Abstract
Lipopeptides are potent adjuvants that trigger an immune response agai nst covalently conjugated low molecular mass antigens. We report here the design and synthesis of thiol-reactive lipopeptides (6, 7) which c an be incorporated into liposomes and react, under mild conditions, wi th synthetic peptides carrying a thiol function. (C) 1998 Elsevier Sci ence Ltd. All rights reserved.