2 NEW MODIFIED TRICHOTHECENES FROM FUSARIUM-SPOROTRICHIOIDES

Authors
FORT DM BARNES CL TEMPESTA MS CASPER HH BEKELE E ROTTINGHAUS AA ROTTINGHAUS GE
Citation
Dm. Fort et al., 2 NEW MODIFIED TRICHOTHECENES FROM FUSARIUM-SPOROTRICHIOIDES, Journal of natural products, 56(11), 1993, pp. 1890-1897
Citations number
16
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
56
Issue
11
Year of publication
1993
Pages
1890 - 1897
Database
ISI
SICI code
0163-3864(1993)56:11<1890:2NMTFF>2.0.ZU;2-R
Abstract
Two new modified trichothecenes, 2-deoxy-11-epi-3alpha-hydroxysambucoi n [1] and 2-deoxy-11-epi-12-acetyl-3alpha-hydroxysambucoin [2], were i solated from Fusarium sporotrichioides culture. This is the first repo rt of modified trichothecenes where the two six-membered rings are cis -fused. Structures were elucidated using gc-ms, nmr, X-my crystallogra phy, and other spectroscopic techniques. Compounds 1 and 2 were screen ed for relative cytotoxicity in cultured baby hamster kidney (BHK-21) cells and found to be non-toxic.