SYNTHESIS OF O-METHYL NIMBINONE

Authors
BURNELL RH DUMONT N THEBERGE N
Citation
Rh. Burnell et al., SYNTHESIS OF O-METHYL NIMBINONE, Journal of natural products, 56(11), 1993, pp. 1930-1936
Citations number
7
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
56
Issue
11
Year of publication
1993
Pages
1930 - 1936
Database
ISI
SICI code
0163-3864(1993)56:11<1930:SOON>2.0.ZU;2-H
Abstract
Two syntheses are described to confirm the structure 15 proposed for n imbinone. The first,which leads to racemic O-methyl nimbinone[14], inv olves the polycyclization of a geraniol-derived intermediate 7. This s ame intermediate also afforded another preparation of (+/-)-methyl nim biol [12]. The other synthesis starts from natural podocarpic acid and affords optically active O-methyl nimbinone [14].