IN-VITRO ACTIVITY OF MERCURIUS-CYANATUS A GAINST RELEVANT PATHOGENIC BACTERIA ISOLATES

The antimicrobial activity of mercurius cyanatus complex (Oligoplex(R) ) and its components Mercurius cyanatus D5, Echinacea anguistfolia D1, Ailanthus glandulosa D3, Ammonium bromatum D3, Baptisia tinctoria D3, Euspongia officinalis D2, alcohol 5% (dilution: D1 = 1 : 10, D2 = 1 : 00 etc.) was tested in vitro by serial dilution tests against 105 cli nical isolates (gram-positive/negative, aerobes and anaerobes with rel evance for pharyngitis). The bactericidal activity was compared with t hat of vancomycin when appropriate. One component of the composition ( Mercurius cyanatus) exerted a considerable bactericidal activity again st S. pyogenes, S. agalactiae, S. pneumoniae, S. aureus, E. faecalis i n serial dilutions of the clinical relevant concentrations D5. However , growth of H. influenzae, Bacteriodes sp. and Actinobacillus actinomy cetemcomitans was not inhibited by Mercurius cyanatus and any other co mponent of the composition. The composition, however, exerted a bacter icidial range similar to that of Mercurius cyanatus, but less efficien t. Analysis of the bactericidial effect of Mercurius cyanatus and vanc omycin revealed comparability for S. pyogenes, S. agalactiae, S. pneum oniae, S. aureus and E. faecalis for vancomycin concentrations of 0.06 3-2 mg/l, which are clinically relevant.