DYSREGULATION OF IN-VITRO TNF-BETA PRODUC TION IN INSULIN-DEPENDENT DIABETES-MELLITUS

Authors
FEUGEAS JP DOSQUET C WAUTIER JL MONTCHAMPMOREAU C KRISHNAMOORTHY R CAILLENS H
Citation
Jp. Feugeas et al., DYSREGULATION OF IN-VITRO TNF-BETA PRODUC TION IN INSULIN-DEPENDENT DIABETES-MELLITUS, Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 316(10), 1993, pp. 1255-1259
Citations number
17
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie → ACNP
ISSN journal
07644469
Volume
316
Issue
10
Year of publication
1993
Pages
1255 - 1259
Database
ISI
SICI code
0764-4469(1993)316:10<1255:DOITPT>2.0.ZU;2-C
Abstract
The possible role of tumor necrosis factors (TNF) in autoimmunity led us to explore the relationship between TNF production, polymorphism of the TNF-beta gene and type one diabetes In the diabetic group we foun d a low production of TNF-beta. This abnormality appeared not to be ex clusively related to the TNF-beta gene and could be also due to polymo rphic regulatory sequences in the major histocompatibility complex reg ion.