PRIMARY ADENOCARCINOMA OF THE URINARY-BLADDER - A REPORT OF 185 CASES

Objective To evaluate the outcome after the treatment of primary non-u rachal vesical adenocarcinoma and to determine the significant prognos tic factors. Patients and methods The records of 185 patients with ves ical adenocarcinoma were reviewed. The pathological evaluation include d the determination of pathological stage, tumour grade, presence or a bsence of mucin and its location, evidence of bilharzial infestation a nd flow-cytometric DNA analysis. The mean follow-up of the treated pat ients was 3.1 years, Disease-free survival was estimated and the resul ts correlated with patient and tumour characteristics (univariate anal ysis), Cox's proportional hazards analysis was used to determine progn ostic factors. Results The overall 5-year disease-free survival was 55 %; only three factors had a significant impact on survival, the tumour pathological stage and grade, and lymph node involvement. Conclusions Radical cystectomy remains the only satisfactory treatment option for primary vesical adenocarcinoma. Tumour stage, grade and lymph node in volvement are the only significant prognostic factors.