CLOSED-LOOP CONTROLLED ADMINISTRATION OF PROPOFOL USING BISPECTRAL ANALYSIS

Ten patients, undergoing elective orthopaedic surgery under spinal ana esthesia, were sedated with propofol using a closed-loop feedback cont rol system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporat ing target-controlled infusion technology combined with a pharmacokine tic-dynamic model. This feedback control system for propofol administr ation proved to be adequate and safe. BIS was found to be well suited as control variable.