THE ALPHA-SYNUCLEIN ALA53THR MUTATION IS NOT A COMMON-CAUSE OF FAMILIAL PARKINSONS-DISEASE - A STUDY OF 230 EUROPEAN CASES

Authors
VAUGHAN J DURR A TASSIN J BEREZNAI B GASSER T BONIFATI V DEMICHELE G FABRIZIO E VOLPE G BANDMANN O JOHNSON WG GOLBE LI BRETELER M MECO G AGID Y BRICE A MARSDEN CD WOOD NW
Citation
J. Vaughan et al., THE ALPHA-SYNUCLEIN ALA53THR MUTATION IS NOT A COMMON-CAUSE OF FAMILIAL PARKINSONS-DISEASE - A STUDY OF 230 EUROPEAN CASES, Annals of neurology, 44(2), 1998, pp. 270-273
Citations number
18
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
44
Issue
2
Year of publication
1998
Pages
270 - 273
Database
ISI
SICI code
0364-5134(1998)44:2<270:TAAMIN>2.0.ZU;2-I
Abstract
We report the results of a screen of 230 European familiar index cases of Parkinson's disease for the recently described Ala53Thr mutation i n the alpha-synuclein gene in an autosomal dominant Parkinson's diseas e kindred. No mutations were found from this broad white population, a nd we therefore conclude that although of great interest, this mutatio n is a very rare cause of familial Parkinson's disease.