IN-VIVO DIFFERENTIATION OF ASTROCYTIC BRAIN-TUMORS AND ISOLATED DEMYELINATING LESIONS OF THE TYPE SEEN IN MULTIPLE-SCLEROSIS USING H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING

We used computer pattern recognition of proton magnetic resonance spec troscopic image data to differentiate between brain tumors and large, isolated, demyelinating lesions of the type seen in multiple sclerosis . Leave-one-out linear discriminant analyses correctly classified reso nance profiles from five acute demyelinating lesions, 20 low-grade ast rocytomas, 22 anoplastic astrocytomas, and 24 glioblastomas. Classific ation of nonacute lesions will require further development, as the met abolic profiles of demyelinating lesions evolve over time.