KILLING OF PSEUDOMONAS-PSEUDOMALLEI BY POLYMORPHONUCLEAR LEUKOCYTES AND PERITONEAL-MACROPHAGES FROM CHICKEN, SHEEP, SWINE AND RABBITS

Differences in the kinetics of Pseudomonas pseudomallei killing by per itoneal macrophages (PM) and polymorphonuclear leucocytes (PMNL) from chickens, sheep, swine and rabbits were found. P. pseudomallei was rap idly killed by porcine PM and PMNL. However the bacterial killing by o vine and lapine PM and PMNL proceeded at a slower rate. In contrast, c hicken PM and PMNL ingested and killed the lowest number of P. pseudom allei bacteria. The differences in the bactericidal activity of PM and PMNL from different animal species correlated with the level of their acid phosphatase and glycolytic activity.