HUMAN T-LYMPHOTROPIC VIRUS TYPE-2 (HTLV-2) PROVIRUS IN CIRCULATING CELLS OF THE MONOCYTE MACROPHAGE LINEAGE IN PATIENTS DUALLY INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND HTLV-2 AND HAVING PREDOMINANTLY SENSORY POLYNEUROPATHY/

Authors
ZEHENDER G MERONI L VARCHETTA S DEMADDALENA C CAVALLI B GIANOTTO M BOSISIO AB COLASANTE C RIZZARDINI G MORONI I GALLI M
Citation
G. Zehender et al., HUMAN T-LYMPHOTROPIC VIRUS TYPE-2 (HTLV-2) PROVIRUS IN CIRCULATING CELLS OF THE MONOCYTE MACROPHAGE LINEAGE IN PATIENTS DUALLY INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND HTLV-2 AND HAVING PREDOMINANTLY SENSORY POLYNEUROPATHY/, Journal of virology, 72(9), 1998, pp. 7664-7668
Citations number
27
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
9
Year of publication
1998
Pages
7664 - 7668
Database
ISI
SICI code
0022-538X(1998)72:9<7664:HTVT(P>2.0.ZU;2-K
Abstract
We investigated the presence of human T-lymphotropic virus type 2 (HTL V-2) DNA in the peripheral blood mononuclear cell subsets obtained fro m 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, f or patients,with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.